Questão FC700280
Leia o texto para responder à questão. In a study of more than 100,000 people, researchers found that those with less healthy lifestyles were more likely to reduce their risk of co
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VUNESP · 2024
Leia o texto para responder à questão.
In a study of more than 100,000 people, researchers found that those with less healthy lifestyles were more likely to reduce their risk of colorectal cancer with regular aspirin use than those with healthier behaviors (JAMA Oncol 2024 Aug 1). Regular aspirin use was defined as two or more 325 mg tablets a week or a daily 81 mg dose; less healthy lifestyles were characterized by higher body mass index, smoking, greater alcohol consumption, less physical activity, and poorer diet. Those with the unhealthiest lifestyles had a 3.4% chance of developing colorectal cancer if they didn’t take aspirin regularly, whereas those who did had a 2.1% chance of developing the disease. In contrast, people with the healthiest lifestyles had a 1.5% chance of developing colorectal cancer if they took aspirin regularly and a 1.6% chance if they didn’t. This result suggests that physicians can pursue a nuanced approach when prescribing aspirin for disease prevention.
(https://aacrjournals.org. 26 de julho a 01 de agosto 2024. Adaptado)
The text is mainly about
- the benefits of taking aspirin daily to treat inflammatory diseases.
- the weight of leading a healthy life for general well-being.
- the probability of developing colorectal cancer after a specific pattern of aspirin intake.
- a recent methodology used in colorectal cancer diagnosis and treatment.
- the recommendation of 325 g of aspirin regardless of health conditions and lifestyle.
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Comentário do professor
A alternativa aponta corretamente que o texto trata da probabilidade de desenvolver câncer colorretal associada a um padrão específico de uso de aspirina. O estudo apresenta riscos absolutos em porcentagem para grupos definidos por estilo de vida e pelo uso de aspirina.
Foi definida aspirina regular como duas ou mais comprimidos de 325 mg por semana ou 81 mg diariamente. Os resultados mostram, por exemplo, 3,4% de risco sem aspirina versus 2,1% com aspirina entre os indivíduos com os piores hábitos.
Isso permite calcular a redução absoluta de risco: \( \Delta = 3{,}4\% - 2{,}1\% = 1{,}3\% \). Entre os com estilos de vida mais saudáveis a diferença foi mínima, ilustrando que o efeito estatístico do uso de aspirina varia conforme o padrão de risco.
Portanto, o foco do texto é quantificar como um padrão específico de uso de aspirina altera a probabilidade de ocorrência da doença.
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